β−Nicotinamide mononucleotide ／ β-NMN CAS 1094-61-7 Health Care Supplement for anti-aging powder
CAS number: 1094-61-7
English name: BETA-NICOTINAMIDE MONONUCLEOTIDE
Synonyms: NMN;β-D-NMN;BETA-NMN;beta-D-NMN;NMN zwitterion;NICOTINAMIDE RIBOTIDE;Nicotinamide nucleotide;Nicotimide mononucleotide;Nicotinamide mononuclotide;NICOTINAMIDE MONONUCLEOTIDE
Appearance: white powder
Purity: over 99%
|1KG foil bag|
Items of analysis
|Appearance||White or almost white crystalline powder||complies|
|Appearance of solution(5%w/v in water)||Colorless to pale yellowand clear||Colorless and clear|
|Storage||Store in sealed containers at cool (4℃)&dry place , protect from light ,moisture and pest infestation|
Beta-Nicotinamide mononucleotide (NMN) is an intermediate of NAD+ biosynthesis produced from nicotinamide through nicotinamide phosphoribosyltransferase (NAMPT) and also referred to as NMN or nicotinamide ribotide. In recent studies of NMN applications to prevention and diagnosis of age-dependent diseases such as diabetes, neurodegenerative disorder, cardiac disease etc., it has become one of hottest biomarkers on discussion for anti-aging, lately. As one of worldwide leading manufacturers, Oriental Yeast Co., Ltd. is now providing highly qualified fully physiologically active, beta-Nicotinamide mononucleotide (NMN) as to support basic research in not only Academia but also Pharmaceuticals.
Brief summary about β-NMN:
NAD+ exists in all living organisms and is well known as a coenzyme in oxidation−reduction reaction. Recent research has drawn attention to its relation to “sirtuin” represented by NAD+−dependent protein deacetylases such as Sirt1 and Sirt3. Because Sirt1 is reported to regulate various life phenomena as aging, people is especially paying high attention to “Anti-aging effect” associated with the activated sirtuin through Sirtuin/SIRT1−activating components (STACs) as represented by resveratrol. Meanwhile, sirtuin is NAD+−dependent and increase of cellular NAD+ level is expected to have similar effects to the STACs, thus nicotinamide mononucleotide, an intermediate of NAD+ biosynthesis, is also in the spotlight.
While absorption of nicotinamide mononucleotide into body and its functional mechanism remain unclear in many respects and are being studied, it is reported that administration tests of nicotinamide mononucleotide into mice show improvement of high fat diet-induced glucose intolerance1), restoration of mitochondrial dysfunction with age2) and reduction of infarct area in response to ischemia/reperfusion3), and that the other chronic administration study in mice indicates rescue effect of age-associated decline in neural stem cells4). Application of nicotinamide mononucleotide for prevention and diagnosis of age-dependent diseases such as diabetes, neurodegenerative disorder, cardiac disease etc. raises high expectation for anti-aging.
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|Product name||CAS number|
|Beta nicotinamide mononucleotide||1094-61-7|
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