Product Details

White Color Nootropic Powder Drugs Sunifiram / DM-235 CAS 314728-85-3 98% Purity

Place of Origin China
Brand Name LSW
Certification ISO9001, KOSHER, USP, GMP
Model Number 314728-85-3
Min.Order Quantity 1 grams
Price Negotiable
Packaging Details Discreet disguised package or as required
Delivery Time 2~7 working days
Payment Terms T/T, , Western Union, MoneyGram, Bitcoin
Supply Ability 5000kg/week

Product Features

Nootropic Drugs Sunifiram / DM-235 CAS 314728-85-3 White Powder

Basic information:

Chemical name: Sunifiram
MF: 246.30492
CAS: 314728-85-3
Appearance: white powder
Purity: over 99%
Package: 1kg/ foil bag


Description:

Sunifiram (DM-235) is a piperazine derived ampakine-like drug which has nootropic effects in animal studies with significantly higher potency than piracetam. IC50 value: Target: in vitro: DM 232 and DM 235 are novel antiamnesic compounds structurally related to ampakines. The involvement of AMPA receptors in the mechanism of action of DM 232 and DM 235 was, therefore, investigated in vivo and in vitro. Both compounds (0.1 mg/kg i.p.) were able to reverse the amnesia induced by the AMPA receptor antagonist NBQX (30 mg/kg i.p.) in the mouse passive avoidance test. At the effective doses, the investigated compounds did not impair motor coordination, as revealed by the rota rod test, nor modify spontaneous motility and inspection activity, as revealed by the hole board test. In mouse hippocampal slices, sunifiram at 10-100 nM significantly enhanced LTP in a bell-shaped dose-response relationship which peaked at 10 nM. The enhancement of LTP by sunifiram treatment was inhibited by 7-chloro-kynurenic acid (7-ClKN), an antagonist for glycine-binding site of NMDAR, but not by ifenprodil, an inhibitor for polyamine site of NMDAR. in vivo: OBX mice were administered once a day for 7-12 days with sunifiram (0.01-1.0 mg/kg p.o.) from 10 days after operation with or without gavestinel (10 mg/kg i.p.), which is glycine-binding site inhibitor of N-methyl-d-aspartate receptor (NMDAR).

Pharmacology:

The mechanism of action of sunifiram is unknown.Sunifiram, as well as unifiram, were assayed at a wide panel of sites, including the most important receptors, ion channels, and transporters, but showed no affinity for any of the sites.They specifically did not bind to the glutamate, GABA, serotonin, dopamine, adrenergic, histamine, acetylcholine, or opioid receptors at concentrations of up to 1 μM.In addition, the drugs were tested on recombinant AMPA receptors and showed no potentiation of the receptors, indicating that they do not act as AMPA receptor positive allosteric modulators.However, they were able to prevent the amnesia induced by the AMPA receptor antagonist NBQX in the passive avoidance test, suggesting that indirect/downstream AMPA receptor activation may be involved in their memory-enhancing effects.

Sunifiram, as well as other nootropics such as piracetam, levetiracetam, and aniracetam are able to antagonize inhibition of glucose transport by barbiturates (e.g., pentobarbital), diazepam, and certain other drugs in human erythrocytes in vitro (Ki = 26.0 uM for sunifiram), and this action has been found to correlate with their potency in reversing scopolamine-induced memory deficits in mice.However, this action has been regarded as very unlikely to represent the main mechanism of action of sunifiram.

Our Advantages:

1. Good reputation:
Our company is a leading chemical company in China, and has more than 16 years history. We have over 10 branch offices, all enjoy good reputation from worldwide customers.

2. High Quality&low price
All of our products have top quality and high purity, since we are the factory, our price is competitive.

3. Multiple payment methods.
We have mutiple payment methods, T/T, Western Unoin, MoneyGram, and Bitcoin for your convenience.

4. Mass Stock
In order to better serve our customers, we are preparing mass stock in our warehouse, we can always ship your parcel within 24 hours.

5. High customs clearance pass rate.
Through 16 years hard work, we have accumulated rich exporting experience to USA, UK, France, Italy, Germany,Spain, Brail, korea, India and so on.We will use special ways to disguise the goods, 98% customs clearance rate is guaranteed, if the delivery is not successful, we will resend for free.

6. Warm After service.
If you have any problems about the goods, do no hesitate to contact us, we can provide 7/24 service.

How to proceed an order:

Nootropics Drug:

Product name CAS number
Sunifiram 314728-85-3
Fasoracetam 110958-19-5
Adrafinil 63547-13-7
Nicotinamide ribose 1341-23-7
Oxiracetam 62613-82-5
Phenylpiracetam 77472-70-9
9-fluorenol 1689-64-1
NSI-189 1270138-40-3
Alpha-GPC 28319-77-9
Citicoline Sodium 33818-15-4
Phenibut 1078-21-3
Unifiram 272786-64-8
PRL-8-53 51352-87-5
Coluracetam 135463-81-9
Noopept 157115-85-0
Beta nicotinamide mononucleotide 1094-61-7
Aniracetam 72432-10-1
Pramiracetam 68497-62-1
Nefiracetam 77191-36-7
NSI-189 phosphate 1270138-41-4
Citicoline 987-78-0
4-Aminobutyric acid 1956-12-2
Sulbutiamine 3286-46-2
Semax 80714-61-0
Galantamine Hydrobromide 69353-21-5




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