Bulk Stock of Phenacetin White Crystal Powder CAS 62-44-2 for Relieving the Pain
Description:
Phenacetin is a synthetic, white crystalline solid that is slightly soluble in water and benzene, soluble in acetone and very soluble in pyrimidine. It is used in research as the preferred marker for detecting CYP1A2-based inhibition potential in vitro. Human ingestion of phenacetin can result in a bluish discoloration of the skin due to a lack of oxygen in the blood (cyanosis), dizziness and respiratory depression. It is reasonably anticipated to be a human carcinogen.
Basic information:
Chemical name: Phenacetin
MF: C10H13NO2
MW: 179.22
CAS: 62-44-2
Purity: over 99%
Appearance: white crystal powder
History:
Phenacetin was introduced in 1887 in Elberfeld by German company Bayer, and was used principally as an analgesic; it was one of the first synthetic fever reducers to go on the market. It is also known historically to be one of the first non-opioid analgesics without anti-inflammatory properties.
Prior to World War One, Britain imported Phenacetin from Germany.During the war, a team including Jocelyn Field Thorpe and Martha Annie Whiteley managed to develop a synthesis in Britain.
Known mechanism of action:
Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.
It is metabolized in the body to paracetamol (acetaminophen), which is also a clinically relevant analgesic.
Dosage:
Analgesic mixtures containing phenacetin were previously marketed as tablets or capsules containing between 150 and 300 mg phenacetin. Common combinations were: 150 mg phenacetin, 230 mg aspirin, and 15 or 30 mg caffeine; or 150 mg phenacetin, 230 mg aspirin, 30 mg caffeine, and 8, 15, 30, or 60 mg codeine phosphate. Phenacetin alone was also available in 250 and 300 mg doses as tablets, and up to 500 mg doses as powder. The usual dose was 300 mg 4–6 times per day, and the daily dose was not to exceed 2 g (IARC, 1977, 1980).
Our Advantages:
1. Top quality with over 99% purity.
2. fresh products directly from the factory.
3. Bulk stock, immediate delivery after payment.
4. We have warehouse in USA and UK, and now is developing warehouse in Canada.
5. Competitive price: 25kg is only US$1000 include door to door shipment by air.
How to proceed an order:
Step2: I will reply you with a quotation as soon as I receive you inquiry.
Step3: We will negotiate products, price, package, payment methods and so on.
Step4: You arrange the payment.
Step5: I will arrange the shipment after receiving you money.
Step6: The tracking number and the picture of the parcel will be sent to you.
Step7: Trace the tracking number on website until you receive the goods.
Step8: If you have any questions about the goods, pls contact me, i will try my best to satisfy you.
If you have any questions, please feel free to contact me.
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Pain Relieving Local Anaesthesia Drugs White Crystal Powder CAS 62-44-2 Images |