Product Details

CAS 62-44-2 Pharmaceutical Raw Material Phenacetin White Crystalline Powder

Place of Origin CN
Brand Name LSW
Certification ISO9001,BRC,KOSHER
Model Number 62-44-2
Min.Order Quantity 10g
Price Negotiation
Packaging Details Discreet package
Delivery Time 5-8 working days
Payment Terms T/T, Western Union, MoneyGram
Supply Ability 5000kg/month

Product Features

CAS: 62-44-2 Pharmaceutical Raw Material Anti Inflammatory Pain Relieving Drugs Phenacetin White Crystalline Powder
Quick Detail:

English name: PHENACETINUM or PHENACETIN

Content: 99%

CAS:62-44-2

Molecular formula: C10H13NO2

Molecular weight: 179.2158

Category: raw material medicine, antipyretic and analgesic drugs raw materials.

Characteristics: This product is white, there is a flash of scale like crystal or white crystalline powder, no

smell, taste bitter. This product is dissolved in ethanol or chloroform, slightly soluble in boiling water

Soluble in water.

Phenacetin description

It is also called acetophenetidin. Having glossy leaflets or scales-like crystals that have no odor or taste. Melting point 134 ~ 137. Stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in ether, soluble in ethanol, chloroform. It is formed through the etherification,reduction and Acetylation reaction of p-chloronitrobenzene. As chloroacetanilide antipyretic and analgesic agent. Suitable for fever, headache, neuralgia and other drugs as a compound agent.

Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic effect. Because the enzyme inhibitor make phenacetin not be converted into paracetamol, still showed obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol. Themild phenacetin analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet.

Applications:
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phenacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincents APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phenacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)).
It was also banned in India.As a result some branded, previously phenacetin-based preparations continued to be sold, but with the phenacetin replaced by safer alternatives. A popular brand of phenacetin was Roches Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phenacetin. Paracetamol is a metabolite of phenacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phenacetins carcinogenicity.
Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research.
COA:
Test Items Specification Test Results
Description Should comply with the standard Pass
Identification Should be positive reaction Pass
Brownish red 4# Pass
4-chloroacetanilide Should comply with standard Pass
Sulphated ash ≤0.1% 0.06%
Melting point 134ºC to 137ºC 134ºC to 137ºC
Appearance ≥99% 100.58%
Conclusion Complies with BP68 edition
Function:

Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin,
low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic
effect. Because the enzyme inhibitor make phenacetins-Acetate not be converted into paracetamol, still showed
obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The
mild phenacetins-Acetate analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid
coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet
.
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