|Synonyms:||p-Acetophenetidide(8CI);4-(Acetylamino)phenetole;4-Ethoxy-1 acetylaminobenzene; 4-Ethoxyacetanilide; 4-Ethoxyacetanilide; Aceto-4-phenetidine; Acetophenetidin; Acetophenetidine; Acetophenetin; Acetphenetidin; Fenidina; Fenina;Kalmin;N-(4-Ethoxyphenyl)acetamide;N-Acetyl-4-ethoxyaniline; N-Acetyl-p-ethoxyaniline;N-Acetyl-p-phenetidine;NSC 7651; Pertonal; Phenacetin; Phenacetine; Phenazetin; Phenedina; Phenidin; Phenin;p-Ethoxyacetanilide;|
|Melting Point:||133-136 °C(lit.)|
|Boiling Point:||355.1 °C at 760 mmHg|
|Flash Point:||168.5 °C|
|Solubility:||0.076 g/100 mL in water|
|Appearance:||white crystalline powder|
Phenacetin is a pain-relieving and fever-reducing drug,it is metabolized as paracetamol (acetaminophen), which replaced it in some over-the-counter medications following the ban on phenacetin.
Its analgesic effects are due to its actions on the sensory tracts of the spinal cord. In addition, phenacetin has a depressant action on the heart, where it acts as a negative inotrope. It is an antipyretic, acting on the brain to decrease the temperature set point. It is also used to treat rheumatoid arthritis (subacute type) and intercostal neuralgia.
Those who have taken drugs that contain phenacetin are more likely to develop cardiovascular disease, high blood pressure, anemia and cancer, and they are at a higher risk of death because of renal failure or diseases of the urinary system, according to various studies. A 1989 study showed that daily users of phenacetin were 5.1 times more likely to develop kidney disease than people who used the drug infrequently. The drug, which was also used in veterinary medicine, was shown to cause benign and malignant tumors in both mice and rats during experimental laboratory studies.
Some over-the-counter painkiller manufacturers replaced phenacetin with paracetamol, a similar drug that has not been shown to be a carcinogen. Paracetamol is also known as acetaminophen. Studies have shown that acetaminophen also can cause damage to the kidneys, but its side effects are not as serious as those of phenacetin.
Phenacetin is now being used as a cutting agent to adulterate cocaine in the UK and Canada, owing to the similar physical features of the two drugs.
Due to low cost phenacetin is used for research into the physical and refractive properties of crystals. It is an ideal compound for this type of research
Phenacetin (or Acetophenetidin) Having glossy leaflets or scales-like crystals that have no odor or taste.
Melting point 134 ~ 137. Stable in air, soluble in water, slightly soluble in boiling water, slightly soluble in ether, soluble in ethanol, chloroform. It is formed through the etherification,reduction and Acetylation reaction of p-chloronitrobenzene. As chloroacetanilide antipyretic and analgesic agent. Suitable for fever, headache, neuralgia and other drugs as a compound agent.
Antipyretic effect is stronger than the analgesic effect. Effect of strength is slow and long-lasting as aspirin, low toxicity. Research shows that: This product and its metabolites acetaminophen have the antipyretic effect. Because the enzyme inhibitor make phenacetin not be converted into paracetamol, still showed obvious antipyretic effect,thus the antipyretic effect after the product line not converrt to paracetamol.The mild phenacetin analgesic effect usually lasts 3 to 4 hours; and synergistic effect, of alicylic acid coadministrationmake the analgesic effect enhancement. The main clinical is for small animal antipyretic analgesic. This product is also a component of the APC tablet.
|Production date||2016.12.27||Shelf life||2019.12.26|
|Items of analysis||Specification||Results|
|Description||Should comply with the standard||Comforms|
|Melting point||134℃ to 136.5℃||134.5℃ to 136.5℃|
|Through a uss#80||98%|
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Phenacetin Pharmaceutical Raw Materials CAS 62-44-2 For Relieving Pain And Hot Images